PUBLICATIONS

 

  1. Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson M.A., Han G.W., Sickmier E.A., Swaminath G, Zhao S. Stevens R.C., Hu L.A., Zhong W, Zhang M, and Xu F*. “Structural Basis for Apelin Control of the Human Apelin ReceptorStructure, 25: 858-866, (2017)

 

  1. Zhang X-J, Zhao F, Wu Y, Yang J, Han G.W., Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin P.R., Gati C, Nelson G, Hunter M.S., Hanson M.A., Cherezov V, Stevens R.C., Tan W, Tao H, and Xu F*. “Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligandNature Communications, 8: 15383, (2017)

 

  1. Ye L, Ding K, Zhao F, Liu X, Wu Y, Liu Y, Xue D, Zhou F, Zhang X, Stevens, R.C., Xu F, Zhao S, Tao H. “A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptorMed. Chem. Commun., 8: 1332, (2017)

 

  1. Zhang X-J, Stevens R.C., Xu F*. “The importance of ligands for G protein-coupled receptor stabilityTrends Biochem Sci, 40(1): 79-87, (2015)

 

  1. Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B, Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis for allosteric regulation of GPCRs by sodium ions Science, 337(6091): 232-236, (2012)

 

  1. Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J, Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors Structure, 20(6): 967-976, (2012)

 

  1. Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, Stevens R.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’-Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment-Based Searching J Med Chem, 55(9): 4297-4308, (2012)

 

  1. Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C, Jacobson K.A.“Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor J Med Chem, 55(1): 538-552, (2012)

 

  1. Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocketTrapping small caffeine in a large GPCR pocket Structure, 19(9): 1204-1207, (2011) Invited Review.

 

  1. Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, Stevens R.C. “Structure of an agonist-bound human A2A adenosine receptor Science, 332: 322-327, (2011)

 

  1. Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid MesophasesCrystal Growth & Design, 11(4): 1193-1201, (2011)